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Waqtigan xaadirka ah, sawirka magnetic resonance imaging (MRI) waxa uu ka soo baxayaa sawir-dhismeed dhaqameed iyo sawir shaqayneed ilaa sawirka molecular. Multi-Nuclear MR Waxay heli kartaa macluumaad kala duwan oo dheef-shiid kiimikaad ah oo ku jira jirka bini'aadamka, iyadoo la ilaalinayo xallinta bannaanka, hagaajinta gaarka ah ee ogaanshaha hababka jireed iyo jireed, oo hadda waa tignoolajiyada kaliya ee awood u leh falanqaynta tirada aan-ka-hortagga lahayn ee dheef-shiid kiimikaad firfircoon ee bini'aadamka ee vivo.

Iyada oo qoto-dheeraanta cilmi-baarista MR-da-badan, waxay leedahay rajooyin ballaadhan oo codsi ah oo ku saabsan baaritaanka hore iyo ogaanshaha burooyinka, cudurrada wadnaha iyo xididada, cudurrada neurodegenerative, nidaamka endocrine, habka dheef-shiidka iyo habka neefsashada, iyo qiimeyn degdeg ah ee habka daaweynta. Philips's madal cilmi baaris caafimaad oo dhinacyo badan leh ayaa ka caawin doonta sawir-qaadista iyo dhakhaatiirta bukaan-socodka inay sameeyaan cilmi-baaris caafimaad oo heersare ah. Dr. Sun Peng iyo Dr. Wang Jiazheng oo ka socda Philips Clinical and Technical Support Department ayaa si faahfaahsan u soo bandhigay horumarinta gees-goynta ee multi-NMR iyo jihada cilmi baarista ee Philips 'cusub multi-core MR Platform cusub.

Resonance Magnetic wuxuu ku guuleystay abaalmarinta Nobel Prize shan jeer taariikhdeeda, dhammaan dhinacyada fiisigiska, kimisteriga, bayoolajiga, iyo daawada, wuxuuna guul weyn ka gaaray mabaadi'da fiisigiska aasaasiga ah, qaab-dhismeedka molecular organic, dhaqdhaqaaqa qaabdhismeedka macromolecular bayooloji, iyo sawir-qaadista caafimaadka. Waxaa ka mid ah, imaging resonance magnetic waxay noqotay mid ka mid ah tignoolajiyada sawir-qaadista caafimaad ee ugu muhiimsan, oo si weyn loogu isticmaalo ogaanshaha cudurrada kala duwan ee qaybaha kala duwan ee jidhka bini'aadamka. Iyadoo horumarinta joogtada ah ee baahiyaha daryeelka caafimaadka, baahida weyn ee ogaanshaha hore iyo qiimeynta waxtarka degdega ah ayaa kor u qaadeysa horumarinta sawirka magnetic resonance imaging ka qaab-dhismeedka dhaqanka (T1w, T2w, PDw, iwm), functional imaging (DWI, PWI, iwm) in imaging molecular (1H MRS Iyo multi-core MRS/MRI).

Asalkii kakan ee 1H ee Tignoolajiyada MR ee ku salaysan, muuqaalada is dulsaaran, iyo isku xidhka biyaha/baruurta ayaa xaddidaya booskeeda sida tignoolajiyada sawirka unugyada. Kaliya tiro xaddidan oo molecules (choline, creatine, NAA, iwm.) ayaa la ogaan karaa, wayna adagtahay in la helo hababka dheef-shiid kiimikaadka molecular ee firfircoon. Iyada oo ku saleysan noocyo kala duwan oo nuclides ah (23Na, 31P, 13C, 129Xe, 17O, 7Li, 19F, 3H, 2H), multi-nuclear MR Waxay heli kartaa noocyo kala duwan oo ah macluumaadka dheef-shiid kiimikaadka ee jirka bini'aadamka, oo leh xallin sare iyo gaar gaar ah, oo hadda waa kan kaliya ee aan soo duulin, metabolites aan sal lahayn, oo aan sal iyo raad lahayn. (glucose, acids amino, acids fatty - non-sun) ee falanqaynta tirada ee hababka dheef-shiid kiimikaad firfircoon ee bini'aadamka.

Iyada oo horumarka joogtada ah ee nidaamka qalabka resonance magnetic, habka isku xigxiga ee degdegga ah (Multi-Band, Spiral) iyo algorithm dardargelinta (dareenka cadaadisay, barashada qoto dheer), MR Imaging / spectroscopy multi-core ayaa si tartiib tartiib ah u bislaaday: (1) waxaa la filayaa inay noqoto qalab muhiim ah oo loogu talagalay bayoolajiga molecular, biochemistry iyo cilmi-baarista dheef-shiid kiimikaadka; (2) Marka ay ka guurto cilmi-baaris cilmi-baaris ah oo ku saabsan daaweynta bukaan-socodka (tijaabooyin caafimaad oo badan oo ku salaysan MR multi-core ayaa sii socda, FIG. 1), waxay leedahay rajooyin ballaadhan oo ku saabsan baaritaanka hore iyo ogaanshaha kansarka, wadnaha iyo xididada, neurodegenerative, dheef-shiid kiimikaadka iyo cudurrada neef-mareenka, iyo qiimeynta waxtarka degdega ah.

Sababo la xiriira mabaadi'da jireed ee kakan iyo dhibka farsamada sare ee MR Field, multi-core MR Waxay ahayd aag cilmi baaris gaar ah oo ka mid ah machadyada cilmi baarista injineerinka ugu sarreeya. In kasta oo multicore MR uu sameeyay horumar la taaban karo ka dib tobanaan sano oo horumar ah, weli waxaa jirta la'aanta xog caafimaad oo ku filan si loo hormariyo goobtan si si dhab ah loogu adeego bukaanka.

Iyada oo ku saleysan hal-abuurnimada joogtada ah ee berrinkii MR, Philips ayaa ugu dambeyntii jabiyay ciribtirka horumarka ee MR-ka badan wuxuuna sii daayay madal cilmi-baaris caafimaad oo cusub oo leh nuclides-ka ugu badan warshadaha. Madalku waa nidaamka kaliya ee xudunta u ah adduunka si uu u helo Shahaadada Wanaagsanaanta Badbaadada Midowga Yurub (CE) iyo shahaadada Maamulka Cunnada iyo Dawooyinka ee Mareykanka (FDA), taasoo awood u siineysa heer-soo-saarka xirmo buuxa oo badan oo MR Solution: Gariirada FDA-ansixisay, caynsanaan buuxa oo buuxa, iyo dib u dhiska heerka saldhigga hawlwadeenka. Isticmaalayaasha uma baahna in lagu qalabeeyo physicists xirfadleyaasha resonance magnetka, injineerada code iyo naqshadeeyayaasha gradient RF, taas oo ka sahlan 1H spectroscopy/imaging dhaqameed. Sare u qaad dhimista kharashyada hawl-qabadka ee MR-ka-badan, u beddelashada bilaashka ah ee u dhexeeya cilmi-baarista sayniska iyo qaabka bukaan-socodka, soo kabashada kharashka ugu dhaqsaha badan, si MR-mudnaha badan u galo rugta caafimaadka.

Multi-core MR hadda waa jihada muhiimka ah ee "Qorshaha Horumarinta Warshadaha Qalabka Caafimaadka ee Shanta Sano", waana tignoolajiyada muhiimka ah ee udub-dhexaadka u ah sawir-qaadista caafimaadka si loo maro habka caadiga ah oo lagu daro biomedicine-ka-goynta. Kooxda saynisyahannada Philips China, oo ay ku kacday wanaajinta cilmi-baarista sayniska ee macaamiisha iyo awoodaha hal-abuurka, waxay sameeyeen cilmi-baaris nidaamsan oo ku saabsan MR-mudnaanta badan. Dr. Sun Peng, Dr. Wang Jiazheng iyo al. marka hore waxay soo jeedisay fikradda MR-nucleomics ee NMR ee Biomedicine (Journal top of the First Region of Spectroscopy of Chinese Academy of Sciences), kaas oo isticmaali kara MR Iyada oo ku saleysan nuclides kala duwan si loo ilaaliyo noocyo kala duwan oo hawlaha unugyada iyo hababka cudurada. Markaa, xukun dhammaystiran iyo qiimayn cudurka iyo daawaynta ayaa la samayn karaa [1]. Fikradda MR Multinucleomics waxay noqon doontaa jihada mustaqbalka ee Horumarinta MR. Warqadani waa dib-u-eegistii ugu horreysay ee nidaamsan ee MR-ka badan ee adduunka, oo daboolaya saldhigga aragtida ee MR-ka badan, cilmi-baarista hore ee kiliinikada, isbeddelka bukaan-socodka, horumarinta qalabka, horumarka algorithm, ku-dhaqanka injineernimada iyo dhinacyo kale (Jaantus 2). Isla mar ahaantaana, kooxda saynisyahanadu waxay iskaashi la sameeyeen Professor Song Bin ee Cusbitaalka Galbeedka Shiinaha si ay u dhammaystiraan maqaalkii ugu horreeyay ee dib u eegis ku saabsan isbeddelka bukaan-socodka ee MR-ka badan ee Shiinaha, kaas oo lagu daabacay joornaalka Insights Imaging [2]. Daabacaadda maqaallo taxane ah oo ku saabsan multicore MR waxay muujineysaa in Philips uu si dhab ah u keenayo xuduudda sawirka molecular multicore ee Shiinaha, macaamiisha Shiinaha, iyo bukaannada Shiinaha. Iyadoo la raacayo fikradda udub-dhexaadka ah ee "Shiinaha, Shiinaha", Philips wuxuu isticmaali doonaa multi-core MR Si kor loogu qaado horumarinta resonance magnetic China iyo caawinta sababta Shiinaha caafimaad leh.

MRI-da nukliyeerka badan waa tignoolajiyada soo baxaysa. Iyadoo horumarinta MR Software iyo hardware, multi-nuclear MRI ayaa lagu dabaqay cilmi-baarista aasaasiga ah iyo tarjumaadda bukaan-socodka ee hababka aadanaha. Faa'iidadeeda gaarka ah waa in ay soo bandhigi karto hababka dheef-shiid kiimikaadka firfircoon ee waqtiga-dhabta ah ee hababka pathological ee kala duwan, sidaas darteed bixinta fursadaha hore ee ogaanshaha cudurrada, qiimeynta waxtarka, go'aan qaadashada daaweynta iyo horumarinta daroogada. Waxaa laga yaabaa inay xitaa ku caawiso sahaminta hababka cusub ee cudur-sidaha.

Si kor loogu qaado horumarinta dheeraadka ah ee goobtan, ka qaybgalka firfircoon ee khabiirada caafimaadka ayaa loo baahan yahay. Horumarinta kliinikada ee aaladaha multicore waa muhiim, oo ay ku jiraan dhismaha nidaamyada aasaasiga ah, jaangooyooyinka teknoolojiyadda, cabbiraadda iyo jaangooyooyinka natiijooyinka, sahaminta tijaabooyinka cusub, is dhexgalka macluumaadka dheef-shiid kiimikaad badan, iwm. Waxaan si adag u aaminsanahay in multi-core MR uu bixin doono marxalad ballaadhan oo loogu talagalay sawir-qaadista iyo khubarada caafimaadka si ay u sameeyaan cilmi-baaris caafimaad, natiijadeeduna waxay faa'iido u yeelan doontaa bukaannada adduunka oo dhan.